Klox Technologies proprietary technology platform utilizes FLE to benefit patients suffering from various skin and soft tissue disorders. FLE harnesses the power of fluorescence to trigger natural living biological systems. Current clinical programs have shown a high degree of efficacy and safety. Klox has developed, and is further developing, several easy to use, pathology-specific FLE to address conditions in the area of Wound Care, Dermatology, Animal Health and Oral Health. FLE has been designed to provide patients with a safe and comfortable experience with little to no downtime.
Publications
Russo A, Mellergaard M, Pellacani G, Nistic S, Nielsen MCE. Fluorescent light energy combined with systemic isotretinoin A 52 weeks follow-up evaluating efficacy and safety in treatment of moderate-severe acne. June 2020. doi10.2254.pdf
Scarcella, G, Gerber, PA, Edge, D, Nielsen, MCE. Effective removal of solar lentigines by combination of pre– And post–fluorescent light energy treatment with picosecond laser treatment. Clin Case Rep. 2020; 00 1– 4. httpsdoi.org10..pd
Edge D., Sch?dt M., Nielsen M.C.E. (2020) Biophotonic Therapy Induced Photobiomodulation. In Fimiani M., Rubegni P., Cinotti E. (eds) Technology in Practical Dermatology. Springer, Cham. ISBN 978-3-030-45350-3; httpsdoi.org10.100797.pd
Gerber PA, Scarcella G, Edge D, Nielsen MCE. Biophotonic pretreatment enhances the targeting of senile lentigines with a 694 nm QS-ruby laser. Photodermatol Photoimmunol Photomed. 2020;36(2)159-160. doi10.1111phpp.12518.pd
Ferroni L, Zago M, Patergnani S, et al. Fluorescent Light Energy (FLE) Acts on Mitochondrial Physiology Improving Wound Healing. J Clin Med. 2020;9(2)1-20. doi10.3390jcm9020559.pdf
Zago M, Dehghani M, Jaworska J, et al. Fluorescence biomodulation in wound healing when is a photon something more 2020;(March)9. doi10.111712.2546694.pdf
Dini V, Janowska A, Davini G, Kerihuel JC, Fauverghe S, Romanelli M. Biomodulation induced by fluorescent light energy versus standard of care in venous leg ulcers A retrospective study. J Wound Care. 2019;28(11)730-736. doi10.12968.pd
Koceva I, Rümmelein B, Gerber PA, Edge D, Nielsen MCE. Fluorescent light energy A new therapeutic approach to effectively treating acne conglobata and hidradenitis suppurativa. Clin Case Reports. 2019;7(9)1769-1772. doi10.1002ccr3.2.pdf
Jalili A. Chromophore gel-assisted phototherapyChromophor-Gel-assistierte Phototherapie. J für ?sthetische Chir. 2019;12(S1)1-5. doi10.1007s12631-018-0121-z.pd
Edge D, Mellergaard M, Dam-Hansen C, et al. Fluorescent light energy The future for treating inflammatory skin conditions J Clin Aesthet Dermatol. 2019;12(5)E61-E68. httpjcadonline.comfle-may-2019..pd
Liu RC, Makhija M, Wong XL, Sebaratnam DF. Treatment of granulomatous rosacea with chromophore gel-assisted phototherapy. Photodermatol Photoimmunol Photomed. March 2019phpp.12463. doi10.1111phpp.12463.pd
Mahendran A, Wong XL, Kao S, Sebaratnam DF. Treatment of erlotinib-induced acneiform eruption with chromophore gel-assisted phototherapy. Photodermatology Photoimmunology and Photomedicine. 2019..pd
Scapagnini G, Marchegiani A, Rossi G, et al. Management of all three phases of wound healing through the induction of fluorescence biomodulation using fluorescence light energy. In Dai T, Wu MX, Popp J, eds. Photonic Diagnosis and T.pdf
Scarcella G, Dethlefsen MW, Nielsen MCE. Treatment of solar lentigines using a combination of picosecond laser and biophotonic treatment. Clin Case Reports. 2018;6(9)1868-1870. doi10.1002ccr3.1749.pdf
Sannino M, Lodi G, Dethlefsen MW, Nisticò SP, Cannarozzo G, Nielsen MCE. Fluorescent light energy Treating rosacea subtypes 1, 2, and 3. Clin Case Reports. 2018;6(12)2385-2390. doi10.1002ccr3.1891.pdf
Davinelli S, Nielsen ME, Scapagnini G. Astaxanthin in skin health, repair, and disease A comprehensive review. Nutrients. 2018;10(4)522. doi10.3390nu10040522.pdf
Fogacci T, Cattin F, Semprini G, Frisoni G, Fabiocchi L, Samorani D. The use of chromophore gel-assisted blue light phototherapy (Lumiheal) for the treatment of surgical site infections in breast surgery. Breast J. 2018;24(6)1135. d.pd
Romanelli M, Piaggesi A, Scapagnini G, et al. Evaluation of fluorescence biomodulation in the real-life management of chronic wounds The EUREKA trial. J Wound Care. 2018;27(11)744-753. doi10.12968jowc.2018.27.11.744.pdf
Nikolis A, Fauverghe S, Scapagnini G, et al. An extension of a multicenter, randomized, split-face clinical trial evaluating the efficacy and safety of chromophore gel-assisted blue light phototherapy for the treatment of acne. Int.pdf
Braun SA, Gerber PA. A photoconverter gel-assisted blue light therapy for the treatment of rosacea. Int J Dermatol. 2017;56(12)1489-1490. doi 10.1111ijd.13724.pd
Nielsen, ME, Devemy E, Jaworksa J et al. Introducing photomodulation by low energy chromophore-induced fluorescent light. Mechanisms of Photobiomodulation. In SPIE Photonics West BIOS Conference January 28 – February 2. San Francisc.pdf
Antoniou C, Dessinioti C, Sotiriadis D, et al. A multicenter, randomized, split-face clinical trial evaluating the efficacy and safety of chromophore gel-assisted blue light phototherapy for the treatment of acne. Int J Dermatol. 20.pd
Nikolis A, Bernstein S, Kinney B, Scuderi N, Rastogi S, Sampalis JS. A randomized, placebo-controlled, single-blinded, split-faced clinical trial evaluating the efficacy and safety of KLOX-001 gel formulation with KLOX light-emittin.pdf
Nikolis A, Fauverghe S, Vezina D, Scapagnini G. non-healing diabetic foot ulcer? A case report. 2016;4(2)25-31. httpwww.diabeticfootcanadajournal.cajournal-contentviewevaluation-of-biophotonic-therapy-in-a-non-healing-diabetic-foot-.pdf
?Nikolis A, Grimard D, Pesant Y, Scapagnini G, Vezina D. A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers. Chronic Wound Care Manag Res. 2016; Volume 3101-111. doi10.214.pdf
